Use of toxicological and chemical models to prioritize DBP research

prepared by Richard J. Bull ... [et al.] ; jointly sponsored by AWWA Research Foundation and U.S. Environmental Protection Agency.
  • 347 Pages
  • 2.85 MB
  • English

AWWA Research Foundation , Denver, CO
Water -- Purification -- Disinfection -- By-products, Drinking water -- Purific
ContributionsBull, Richard J., AWWA Research Foundation., United States. Environmental Protection Agency.
LC ClassificationsTD459 .U84 2006
The Physical Object
Paginationxxxii, 347 p. :
ID Numbers
Open LibraryOL22558683M
ISBN 101583214771
ISBN 139781583214770
LC Control Number2007273793

Description Use of toxicological and chemical models to prioritize DBP research EPUB

Use of Toxicological and Chemical Models to Prioritize Dbp Research (Awwarf Report Series) by Richard J. Bull (Author), David A. Reckhow (Author), Vincent. Use of Toxicological and Chemical Models to Prioritize DBP Research. Report # 06/19/ 06/19/ View Executive Summary. Subscriber Use of Toxicological and Chemical Models to Prioritize DBP Research.

Publication. 06/19/ 06/19/ Related Projects. Recently. Project # Post-Optimization Lead and Copper Control Monitoring. Halobenzoquinones (HBQs), a new class of disinfection byproducts (DBPs), occur widely in treated drinking water and recreational water.

The main concern regarding human exposure to DBPs stems from epidemiological studies that have consistently linked the consumption of chlorinated drinking water with an increased risk of developing bladder by: The discovery of previously unknown DBPs through emerging advanced analytical techniques is critical to understand the total DBP exposure load, but toxicological evidence is necessary to support the identification and occurrence of a novel compound as an emerging DBP of toxicological relevance (Hrudey and Fawell, ; Li and Mitch, ).Cited by: 2.

Since their discovery, disinfection by-products (DBPs) have become one of the major driving forces in drinking water regulations, research and water utility operations throughout the world. The list of DBPs that can occur in treated drinking waters has grown from a few trihalomethanes to a long list of halogenated and non-halogenated organic or inorganic compounds.

1. Introduction. Evaluating the individual and combined mixture effects of chemicals on biological systems has always been an enduring topic in toxicological studies (Hamid et al., ).Recently, the combined toxicity assessment has gained experiential support for prioritizing the emerging pollutants based on their toxic potentials using advance in vitro and vivo bioassays (Junaid.

While DBP exposures are associated with a number of health effects, this study focuses on (1) mutagenic activity of DBP mixtures, (2) DBP cancer epidemiology, and (3) toxicology studies to. In silico toxicology is one type of toxicity assessment that uses computational methods to analyze, simulate, visualize, or predict the toxicity of chemicals.

In silico toxicology aims to complement existing toxicity tests to predict toxicity, prioritize chemicals, guide toxicity tests, and minimize late‐stage failures in drugs design. There. A method based on regression-modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection.

Use of toxicological and chemical models to prioritize DBP research Denver, CO AwwaRF and AWWA. Google Scholar Cancho B., Ventura M., Galceran M., Diaz A.& Ricart S. Toxicological Research is the official journal of the Korean Society of Toxicology.

The journal covers all areas of toxicological research of chemicals, drugs and environmental agents affecting human and animals, which in turn impact public health. Occurrence. Regulated ng-water quality is regulated in most countries, and monitoring is conducted routinely.

A complete list of chemicals that are currently regulated in drinking water, and the regulatory limits promulgated for each chemical by the WHO (), the U.S.

Environmental Protection Agency (EPA ), and the European Union (EU) Council () are. Chen B, Zhang T, Bond T and Gan Y () Development of quantitative structure activity relationship (QSAR) model for disinfection byproduct (DBP) research: A review of methods and resources, Journal of Hazardous Materials, /t,(), Online publication date: 1.

The U.S. Environmental Protection Agency’s “Four Lab Study” involved participation of researchers from four national Laboratories and Centers of the Office of Research and Development along with collaborators from the water industry and academia.

The study evaluated toxicological effects of complex disinfection byproduct (DBP) mixtures, with an emphasis on reproductive and. History: Toxicology Research rment in Europe, of ist.

Thus toxicology, in its scope, casts a broad net, encompassing hazardous effects of chemicals (including drugs, industrial chemicals and pesticides), biological agents, also known as toxins (e.g., poisonous plants and venomous animals) and physical agents (e.g., radiation, noise).

This article outlines the basics of toxicology and explores where the research in this field is heading. Toxicology is the study of the adverse effects of chemical agents or radiation on living organisms.

The field of toxicology has existed since the beginning of recorded history, evolving from the ancient use of poisons for hunting and warfare. methods to characterize toxicity pathways, prioritizing compounds for more extensive toxicological evaluation, and developing predictive models for biological response in humans and the environment.

To help achieve these goals, the Tox21 partners created a compound library of ∼10, agency-relevant chemical samples to be screened in a battery of. Rate this book. Clear rating. How to Use Financial Ratios to Maximise Value and Success for Your Business [With CDROM] again.

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Clear rating. 1 of 5 stars 2 of 5 stars 3 of 5 stars 4 of 5 stars 5 of 5 stars. Use of Toxicological and Chemical Models to Prioritize Dbp Research by. Richard Bull, Vincent Rotello/5(2).

Register a free Taylor & Francis Online account today to boost your research and gain these benefits: Drug and Chemical Toxicology, Vol Issue 6 () Research Articles.

Article. Bibliometric profile of global scientific research on digoxin toxicity (–). With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.

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Both seasoned mixtures researchers and those. Unlike the current study using Xenopus laevis, toxicological studies using a mammalian model to study the effects of DBP, at relatively low doses, were unable to detect subtle changes in the testis.

Thus, Xenopus laevis is perhaps a good model to study the low-dose effects of DBP on early development and sexual differentiation. Systematic, comparative, in vitro toxicological data provides the water supply community with information to consider when employing alternatives to chlorine disinfection.

In addition, these data aid in prioritizing DBPs and their related compounds for future in vivo toxicological studies and risk assessment. Characterizing toxic effects for industrial chemicals carries the challenge of focusing resources on the greatest potential risks for human health and the environment.

The union of molecular modeling, bioinformatics and simulation of complex systems with emerging technologies such as genomics and proteomics has created the possibility of developing a new strategy to prioritize the testing of.

Suggested Citation:"6 Research Priorities to Support Dispersant Use Decision-Making."National Research Council. Oil Spill Dispersants: Efficacy and gton, DC: The National Academies Press. doi: /   Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Clinical Sciences Building, Edmonton, Alberta, Canada T6G 2G3.

Use of Toxicological and Chemical Models to Prioritize DBP Research. Denver, CO. Awwa Research Foundation. Google Scholar. Dibutyl phthalate (DBP) disrupts male sexual development through testosterone inhibition and fertility through reduced spermatogenesis. Previously, separate PBPK models were developed for serum metabolite kinetics in adult male (Keys et al, Toxicol ) and pregnant female rats.

Dibutyl Phthalate (DBP) Show Project Details Hide Project Details There is a need for methods to screen and prioritize chemicals for potential hazard, a human P 3A cluster or chimeric mice transplanted with human hepatocytes have been introduced into the human toxicology research area.

In this review, drug metabolism and disposition. EPA’s computational toxicology research efforts evaluate the potential health effects of thousands of chemicals. The process of evaluating potential health effects involves generating data that investigates the potential harm, or hazard of a chemical, the degree of exposure to chemicals as well as the unique chemical characteristics.

Animal Models Differences in Susceptibility to Infection by Specific Pathogens Example: • Adenovirus vector toxicology • Adenoviruses are currently use in gene therapy and in particular for development of oncolytic virus vectors for treatment of cancer.

• Mice and rats are the most commonly used rodent models for safety testing. DBP number, chemical type and concentration are dependent on source-water and treatment-scenario characteristics.

Although more than DBPs have been identified, ~50% of the total organic halide (TOX) mass formed during chlorination remains unidentified. Developing a Research Strategy for the Integrated Toxicological and Chemical Evaluation of Complex Drinking Water DBP Mixtures S4HE Response-Surface Modeling of the Effect of 5alpha-Dihydrotestosterone and Androgen Receptor Levels on the Response to the.

Repositories of chemical property data are valuable for supporting computational toxicologists by providing access to data regarding potential toxicity issues with compounds as well as for the purpose of building structure–toxicity relationships and associated prediction models. These relationships use mathematical, statistical, and modeling.FutureTox II explored a broad range of current toxicological research to address those and other questions.

Priority concerns and emerging areas in the field of predictive toxicology are summarized in Box ty concerns include, for example, predicting, modeling, or experimentally evaluating the role of metabolism on toxicological outcomes; modeling chemical mixtures; understanding the.